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- Deep Dive into the Management of Myelodysplastic Syndromes
- The Changing Landscape of Myelodysplastic Syndromes Treatment
- Some Highlighted Studies

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- Clinical Insights into Managing Myeloma
- Challenges in Multiple Myeloma: Renal Failure
- Some Highlighted Studies

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- Deciding the Optimum Treatment Options for Acute Myeloid Leukemia
- Deep Dive into the Acute Myeloid Leukemia Treatment Scenario
- New Evidence and Innovative Therapeutics in Acute Myeloid Leukemia
- Some Highlighted Studies

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#### View

# Multiple Myeloma

### Challenges in Multiple Myeloma: Renal Failure

##### How to Manage Common Challenging Situations in Patients With Multiple Myeloma: Management of Multiple Myeloma in Patients With Renal Failure

###### Speaker details: Dr. Francesca Gay

Renal failure is present in 20%–40% of newly diagnosed patients and, if severe, is associated with increased early death.18 Anti-MM treatment should start immediately to restore renal function, and further adverse events should be prevented and managed to optimize patient outcomes.

First-line treatment in patients with renal impairment should include a bortezomib-based strategy.19

Lenalidomide and pomalidomide can also be used safely.20,21

The second-generation proteasome inhibitor carfilzomib is also effective, but careful monitoring of renal and cardiovascular toxicities is warranted.22

The addition of monoclonal antibodies to novel agent combinations is safe and effective at both diagnosis and relapse.23

In eligible patients, autologous stem cell transplant should be considered (even in dialysis-dependent patients).19