Why loading dose for Pertuzumab in PHESGO but not in Trastuzumab SC?

Variation in efficacy in
low & high BMI setting?

Improvemment in the efficiency of health care system?

Higher rates of
IRRS/ ARRS in PHESGO arm of FeDeriCa compared with Perjeta+ Trastuzumab IV arm?

Fixed dose cannot be altered for underweight patients?

Diarrhea common with PHESGO than Pertuzumab?

Why shift to PHESGO over Pertuzumab IV?