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How SpinCura Works ?

How SpinCura Works
SpinCura is an ASO (Antisense Oligonucleotide) that alters SMN2 gene splicing to increase SMN protein synthesis by correcting the disease's underlying cause.
SpinCura contains Nusinersen that belongs to a group of medicines known as antisense oligonucleotides (ASO). Treating 5q Spinal Muscular Atrophy (5q SMA) is the only application for Nusinersen.
Spinal muscular atrophy (SMA) is a genetic disease affecting the central nervous system, peripheral nervous system, and voluntary muscle movement. It primarily affects motor neurons in the spinal cord, which lack the survival motor neuron (SMN) protein. Atrophy occurs when muscles are not stimulated by nerve cells. Human cells need the SMN1 and SMN2 genes to make the SMN protein. The SMN2 gene, which typically generates just 10% of the SMN protein and is not as functional as a full-length protein. The SMN1 gene is mutated or deleted in the SMA patients. Nusinersen assists these patients making the SMN2 gene to produce full length (100%) SMN protein essential for normal function of motor neurons.
Spincura is an ASO (Antisense Oligonucleotide) that includes Nusinersen, a drug used only to treat Spinal Muscular Atrophy (5q SMA) by changing the splicing of the SMN2 gene.

Who Needs the Treatment ?

Based on the signs, symptoms and the type of SMA, the Health Care Professional decides the treatment plan.

Following the identification of the underlying genetic aetiology of SMA, therapy strategies with drug like Spincura that target the SMA-related genes can be opted. Early treatment can significantly extend life expectancy and enhance the quality of life for individuals.

Signs and Symptoms of SMA.

Based on the signs, symptoms and the type of SMA, the Health Care Professional decides the treatment duration and effective working of SpinCura.
Muscle Weakness
Muscle weakness
Unable to Stand and Walk
Unable to Stand and Walk
Involuntary trembling (tremors) in their fingers
Involuntary trembling (tremors) in their fingers
Scoliosis
Scoliosis(spine that curves side-to-side)
Respiratory muscle weakness that can be life-threatening
Respiratory muscle weakness that can be life-threatening

SMA Type:

SpinCura (Nusinersen) is specifically used to treat various types of SMA as specified below:
Assist untreated children who does not have the muscular strength to sit unassisted, with a life expectancy of around 2 years in SMA type 1 and SMA type 2 patients.
It can fight against the respiratory challenges and control the progression of the disease in patients with SMA of all types.
It helps maintain their daily routine by decreasing the muscle weakness in the patients with type 3 and type 4 SMA that emerges in children of 18 months old or older.
In situations of aggressive SMA of types 1 and 2, SpinCura treatment prolongs the life span of the patients.

Safety Profile:

Blood and urine testing: Individuals on SpinCura may be at similar risk because comparable drugs have been shown to raise the risk of bleeding and kidney injury.
To check for indications of these hazards, it is advised that your healthcare provider (HCP) complete blood and urine tests before starting therapy and again before each dosage.

Common Side Effects:

Based on clinical trials, lower respiratory infections, fever, constipation, headaches, vomiting, back discomfort, and post-lumbar puncture syndrome (a headache caused by the intrathecal administration) were among the most frequent side effects.

Important Safety Information

Similar medications have been associated with an increased risk of bleeding problems. Before you begin SpinCura medication and before each dosage, your healthcare practitioner should run blood tests to check for indications of these risks. In the event of sudden bleeding, get medical help.
Similar medications have been associated with an increased risk of kidney injury, including acute renal inflammation that can be deadly. Urine testing should be done by your healthcare practitioner both before you begin SpinCura medication and before each dosage in order to check for indications of this risk.
Lower respiratory infections, fever, constipation, headaches, vomiting, back discomfort, and post-lumbar puncture syndrome are among the most typical adverse effects of SpinCura.
These aren't the only potential adverse effects of SpinCura. If you would want medical advice regarding side effects, contact your physician. Adverse events can also be reported by calling +91 4023544875/ 76/ 77 or mailing to [email protected], you can report adverse effects.
Inform your healthcare practitioner if you are pregnant or want to become pregnant before starting SpinCura.